Molecular insights into the mechanisms of susceptibility of Labeo rohita against oomycete Aphanomyces invadans.
Identifieur interne : 000108 ( Main/Exploration ); précédent : 000107; suivant : 000109Molecular insights into the mechanisms of susceptibility of Labeo rohita against oomycete Aphanomyces invadans.
Auteurs : P K Pradhan [Inde] ; Dev Kumar Verma [Inde] ; Luca Peruzza [Royaume-Uni, Italie] ; Shubham Gupta [Inde] ; Syed Assim Haq [Inde] ; Sergei V. Shubin [Royaume-Uni] ; Kenton L. Morgan [Royaume-Uni] ; Franziska Trusch [Royaume-Uni] ; Vindhya Mohindra [Inde] ; Chris Hauton [Royaume-Uni] ; Pieter Van West [Royaume-Uni] ; Neeraj Sood [Inde]Source :
- Scientific reports [ 2045-2322 ] ; 2020.
Abstract
Aphanomyces invadans, the causative agent of epizootic ulcerative syndrome, is one of the most destructive pathogens of freshwater fishes. To date, the disease has been reported from over 160 fish species in 20 countries and notably, this is the first non-salmonid disease that has resulted in major impacts globally. In particular, Indian major carps (IMCs) are highly susceptible to this disease. To increase our knowledge particularly with regards to host immune response against A. invadans infection in a susceptible host, the gene expression profile in head kidney of A. invadans-infected and control rohu, Labeo rohita was investigated using RNA sequencing. Time course analysis of RNA-Seq data revealed 5608 differentially expressed genes, involved among others in Antigen processing and presentation, Leukocyte transendothelial migration, IL-17 signaling, Chemokine signaling, C-type lectin receptor signaling and Toll-like receptor signaling pathways. In the affected pathways, a number of immune genes were found to be downregulated, suggesting an immune evasion strategy of A. invadans in establishing the infection. The information generated in this study offers first systematic mechanistic understanding of the host-pathogen interaction that might underpin the development of new management strategies for this economically devastating fish-pathogenic oomycete A. invadans.
DOI: 10.1038/s41598-020-76278-w
PubMed: 33177569
PubMed Central: PMC7658212
Affiliations:
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Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002</wicri:regionArea><wicri:noRegion>226 002</wicri:noRegion></affiliation></author><author><name sortKey="Verma, Dev Kumar" sort="Verma, Dev Kumar" uniqKey="Verma D" first="Dev Kumar" last="Verma">Dev Kumar Verma</name><affiliation wicri:level="1"><nlm:affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002</wicri:regionArea><wicri:noRegion>226 002</wicri:noRegion></affiliation></author><author><name sortKey="Peruzza, Luca" sort="Peruzza, Luca" uniqKey="Peruzza L" first="Luca" last="Peruzza">Luca Peruzza</name><affiliation wicri:level="1"><nlm:affiliation>School of Ocean and Earth Science, University of Southampton, Waterfront Campus, European Way, Southampton, SO14 3ZH, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Ocean and Earth Science, University of Southampton, Waterfront Campus, European Way, Southampton, SO14 3ZH</wicri:regionArea><wicri:noRegion>SO14 3ZH</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020, Legnaro (PD), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020, Legnaro (PD)</wicri:regionArea><wicri:noRegion>Legnaro (PD)</wicri:noRegion></affiliation></author><author><name sortKey="Gupta, Shubham" sort="Gupta, Shubham" uniqKey="Gupta S" first="Shubham" last="Gupta">Shubham Gupta</name><affiliation wicri:level="1"><nlm:affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002</wicri:regionArea><wicri:noRegion>226 002</wicri:noRegion></affiliation></author><author><name sortKey="Haq, Syed Assim" sort="Haq, Syed Assim" uniqKey="Haq S" first="Syed Assim" last="Haq">Syed Assim Haq</name><affiliation wicri:level="1"><nlm:affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002</wicri:regionArea><wicri:noRegion>226 002</wicri:noRegion></affiliation></author><author><name sortKey="Shubin, Sergei V" sort="Shubin, Sergei V" uniqKey="Shubin S" first="Sergei V" last="Shubin">Sergei V. Shubin</name><affiliation wicri:level="1"><nlm:affiliation>College of Science, Swansea University, Singleton Park, Swansea, SA2 8PP, Wales, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>College of Science, Swansea University, Singleton Park, Swansea, SA2 8PP, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Morgan, Kenton L" sort="Morgan, Kenton L" uniqKey="Morgan K" first="Kenton L" last="Morgan">Kenton L. Morgan</name><affiliation wicri:level="1"><nlm:affiliation>The Institute of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Liverpool, CH64 7TE, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Liverpool, CH64 7TE</wicri:regionArea><wicri:noRegion>CH64 7TE</wicri:noRegion></affiliation></author><author><name sortKey="Trusch, Franziska" sort="Trusch, Franziska" uniqKey="Trusch F" first="Franziska" last="Trusch">Franziska Trusch</name><affiliation wicri:level="1"><nlm:affiliation>International Centre for Aquaculture Research and Development, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Centre for Aquaculture Research and Development, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland</wicri:regionArea><wicri:noRegion>Scotland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Dundee, School of Life Sciences, Department of Plant Sciences (@ James Hutton Institute), Invergowrie, Dundee, DD2 5DA, Scotland, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Dundee, School of Life Sciences, Department of Plant Sciences (@ James Hutton Institute), Invergowrie, Dundee, DD2 5DA, Scotland</wicri:regionArea><wicri:noRegion>Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Mohindra, Vindhya" sort="Mohindra, Vindhya" uniqKey="Mohindra V" first="Vindhya" last="Mohindra">Vindhya Mohindra</name><affiliation wicri:level="1"><nlm:affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002</wicri:regionArea><wicri:noRegion>226 002</wicri:noRegion></affiliation></author><author><name sortKey="Hauton, Chris" sort="Hauton, Chris" uniqKey="Hauton C" first="Chris" last="Hauton">Chris Hauton</name><affiliation wicri:level="1"><nlm:affiliation>School of Ocean and Earth Science, University of Southampton, Waterfront Campus, European Way, Southampton, SO14 3ZH, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Ocean and Earth Science, University of Southampton, Waterfront Campus, European Way, Southampton, SO14 3ZH</wicri:regionArea><wicri:noRegion>SO14 3ZH</wicri:noRegion></affiliation></author><author><name sortKey="Van West, Pieter" sort="Van West, Pieter" uniqKey="Van West P" first="Pieter" last="Van West">Pieter Van West</name><affiliation wicri:level="1"><nlm:affiliation>International Centre for Aquaculture Research and Development, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Centre for Aquaculture Research and Development, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland</wicri:regionArea><wicri:noRegion>Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Sood, Neeraj" sort="Sood, Neeraj" uniqKey="Sood N" first="Neeraj" last="Sood">Neeraj Sood</name><affiliation wicri:level="1"><nlm:affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India. sood_neeraj@rediffmail.com.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002</wicri:regionArea><wicri:noRegion>226 002</wicri:noRegion></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aphanomyces invadans, the causative agent of epizootic ulcerative syndrome, is one of the most destructive pathogens of freshwater fishes. To date, the disease has been reported from over 160 fish species in 20 countries and notably, this is the first non-salmonid disease that has resulted in major impacts globally. In particular, Indian major carps (IMCs) are highly susceptible to this disease. To increase our knowledge particularly with regards to host immune response against A. invadans infection in a susceptible host, the gene expression profile in head kidney of A. invadans-infected and control rohu, Labeo rohita was investigated using RNA sequencing. Time course analysis of RNA-Seq data revealed 5608 differentially expressed genes, involved among others in Antigen processing and presentation, Leukocyte transendothelial migration, IL-17 signaling, Chemokine signaling, C-type lectin receptor signaling and Toll-like receptor signaling pathways. In the affected pathways, a number of immune genes were found to be downregulated, suggesting an immune evasion strategy of A. invadans in establishing the infection. The information generated in this study offers first systematic mechanistic understanding of the host-pathogen interaction that might underpin the development of new management strategies for this economically devastating fish-pathogenic oomycete A. invadans.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">33177569</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>11</Month><Day>11</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Molecular insights into the mechanisms of susceptibility of Labeo rohita against oomycete Aphanomyces invadans.</ArticleTitle><Pagination><MedlinePgn>19531</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-020-76278-w</ELocationID><Abstract><AbstractText>Aphanomyces invadans, the causative agent of epizootic ulcerative syndrome, is one of the most destructive pathogens of freshwater fishes. To date, the disease has been reported from over 160 fish species in 20 countries and notably, this is the first non-salmonid disease that has resulted in major impacts globally. In particular, Indian major carps (IMCs) are highly susceptible to this disease. To increase our knowledge particularly with regards to host immune response against A. invadans infection in a susceptible host, the gene expression profile in head kidney of A. invadans-infected and control rohu, Labeo rohita was investigated using RNA sequencing. Time course analysis of RNA-Seq data revealed 5608 differentially expressed genes, involved among others in Antigen processing and presentation, Leukocyte transendothelial migration, IL-17 signaling, Chemokine signaling, C-type lectin receptor signaling and Toll-like receptor signaling pathways. In the affected pathways, a number of immune genes were found to be downregulated, suggesting an immune evasion strategy of A. invadans in establishing the infection. The information generated in this study offers first systematic mechanistic understanding of the host-pathogen interaction that might underpin the development of new management strategies for this economically devastating fish-pathogenic oomycete A. invadans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pradhan</LastName><ForeName>P K</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verma</LastName><ForeName>Dev Kumar</ForeName><Initials>DK</Initials><AffiliationInfo><Affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peruzza</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>School of Ocean and Earth Science, University of Southampton, Waterfront Campus, European Way, Southampton, SO14 3ZH, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020, Legnaro (PD), Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Shubham</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haq</LastName><ForeName>Syed Assim</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shubin</LastName><ForeName>Sergei V</ForeName><Initials>SV</Initials><AffiliationInfo><Affiliation>College of Science, Swansea University, Singleton Park, Swansea, SA2 8PP, Wales, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morgan</LastName><ForeName>Kenton L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>The Institute of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Liverpool, CH64 7TE, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trusch</LastName><ForeName>Franziska</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>International Centre for Aquaculture Research and Development, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Dundee, School of Life Sciences, Department of Plant Sciences (@ James Hutton Institute), Invergowrie, Dundee, DD2 5DA, Scotland, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohindra</LastName><ForeName>Vindhya</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, Uttar Pradesh, 226 002, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauton</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Ocean and Earth Science, University of Southampton, Waterfront Campus, European Way, Southampton, SO14 3ZH, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van West</LastName><ForeName>Pieter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>International Centre for Aquaculture Research and Development, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sood</LastName><ForeName>Neeraj</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. 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Morgan</name><name sortKey="Shubin, Sergei V" sort="Shubin, Sergei V" uniqKey="Shubin S" first="Sergei V" last="Shubin">Sergei V. Shubin</name><name sortKey="Trusch, Franziska" sort="Trusch, Franziska" uniqKey="Trusch F" first="Franziska" last="Trusch">Franziska Trusch</name><name sortKey="Trusch, Franziska" sort="Trusch, Franziska" uniqKey="Trusch F" first="Franziska" last="Trusch">Franziska Trusch</name><name sortKey="Van West, Pieter" sort="Van West, Pieter" uniqKey="Van West P" first="Pieter" last="Van West">Pieter Van West</name></country><country name="Italie"><noRegion><name sortKey="Peruzza, Luca" sort="Peruzza, Luca" uniqKey="Peruzza L" first="Luca" last="Peruzza">Luca Peruzza</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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